Abstract

PREPARATION, CHARACTERIZATION AND EVALUATION STUDY OF FLUCONAZOLE VANISHING CREAM

Manohar Yadav*, Popin Kumar, Yogita Tyagi, Archana Rautela and Praveen Kumar Ashok

ABSTRACT

The purpose of this article is to overcome the systemic adverse effect of fluconazole that is hepatotoxicity and nephrotoxicity by topical application of fluconazole. Fluconazole is an azole antifungal and used in the treatment of local and systemic fungal infections like tinea corporis, onychomycosis and dermatophytosis. For efficient delivery of drug to skin tissue, a fluconazole vanishing cream was not develop till date. But we can found various formulations like fluconazole capsule, tablets etc. Skin creams are generally W/O and O/W .In the sin cream various vitamins like vit. A,E and D3 and fatty acid used. The objective of the research article study is to treat various fungal diseases. Physical mixture of the surfactant base and fluconazole was also prepared as a control formulation to evaluate the various effects. The vanishing cream was made based on the various evaluation parameter and types of polymer used. So, Fluconazole vanishing cream formulation was developed in this study and is promising for better patient compliance as no any traces when applied.

Keywords: Fluconazole, Emollients, Dermatophytosis, Candida krusei.