Abstract

A CONCISED REVIEW ON SUSTAINED RELEASE DRUG DELIVERY SYSTEM WITH RECENT TRENDS

K. Sundaramoorthy*, S. Geetha, V. Dhatchayani

ABSTRACT

Now a days as the expenditure and problems involved in marketing new drug entities are increased, with concomitant recognition of the therapeutic advantages of Sustained release drug delivery, greater attention has been focused on development of sustained or controlled release drug delivery systems (DDS). Sustained release dosage forms are designed to release a drug at a predetermined rate by maintaining a constant drug level for a specific period of time with minimum side effects. Oral Sustained release formulation provide an advantage over conventional dosage forms by optimizing bio-pharmaceutics, pharmacokinetic and pharmacodynamics properties of drugs in such a way that it reduces dosing frequency to an extent that once daily dose is sufficient for therapeutic management through uniform plasma concentration providing maximum utility of drug with reduction in local and systemic side effects and cure or control condition in shortest possible time by smallest quantity of drug to assure greater patient compliance. Present review article compile various formulation approaches for sustained release drug delivery system such as advantages, disadvantages, challenges, factors in designing of SRDDS, drug selection, polymers used, classification and evaluation of SRDDS and finally concluded with recent trends.

Keywords: SRDDS, Factors, Types of matrix and polymer, evaluation, Recent trends.