Abstract

EXPERIMENTAL EVALUATION OF WOUND HEALING ACTIVITY OF IXORA POLYANTHA WIGHT. LEAF-A FOLKLORE DRUG

Dr. Anupama K. N.*, Dr. Naveen V. and Dr. Manjunath P. Mudgal

ABSTRACT

Background: Cutaneous wound have high incidence in India. Ixora polyantha wight is a folklore herb used in coastal regions of Karnataka for wound healing. It is necessary to scientifically validate its efficacy in wound healing. An experimental in-vivo study was carried out to assess the role of Ixora polyantha Wight in the treatment of Excised wound. Aim: The study was carried out to evaluate the wound healing activity of Ixora polyantha Wight. leaves in Wistar albino rats. Materials and Methods: Excision wound model was selected for the study using 3 groups, Control group, Standard and Trial group respectively each group containing 6 rats. In Control group no medication was administered, Leaf paste of Jasminum grandiflorum was used as Standard and Ixora polyantha Wight. leaf paste was used
as trial drug. Leaf paste of both the drugs were applied externally. The assessment criteria are wound contraction percentage and number of days of epithelisation and histopathological study of wound tissue. Results: The experimental study showed that, Ixora polyantha Wight. had faster rate of wound healing in first 7 days when compared to Jasminum grandiflorum Linn. (Standard group) and Control group however, standard group was highly significant when compared to trial group at the end of 14 days. Histopathological study results revealed that the wound tissue is healthier in both Standard group and Trial group.

Keywords: Wound, Ixora, Folklore, In-vivo.