Abstract

SYNTHESIS, CHARACTERIZATION AND BIOACTIVITY STUDY OF COBALT COMPLEXES WITH 5, 5-DIMETHYLCYCLOHEXANE 1, 3-DIONE DERIVATIVES

Kavita S. Mundhe* and Gayatri S. Kamble

ABSTRACT

The present study describes the synthesis of cobalt (II) complexes of Schiff bases derived from condensation reaction of 3, 3 – dimethyl 1, 3 –cyclohexane dione with aniline and substituted anilines. The synthesized cobalt complexes of 5, 5-dimethyl-3-(phenylimino) cyclohexanone (L1), 5, 5 -dimethyl-3-(o-phenylimino) cyclohexanone (L2), 5,5-dimethyl-3-(m-phenylimino) cyclohexanone (L3), 5,5-dimethyl-3-(p-phenylimino) cyclohexanone (L4) have been characterized by using spectral techniques, magnetic study and thermogravimetric analysis. These metal complexes have been evaluated for their antimicrobial and anthelmintic activity. It is observed that the Schiff bases are coordinated to metal ions through amine nitrogen and oxygen of carbonyl group. The anti microbial study shows that the cobalt complexes show better activity against bacterial strain Staphylococcus aureus in comparison to the ligands. The cobalt complex shows significant anthelmintic activity.

Keywords: Dimedone derivatives, Cobalt Complexes, Spectral and Antimicrobial study.