Abstract

SYNTHESIS, CHARACTERIZATION & ANTI-CONVULSANT ACTIVITY OF SOME NEWER QUINOLINE BASED DERIVATIVES

Ashutosh Chand Kaushal*, Sujeet Kumar Gupta, Ram Sevak Verma and Shobhit Srivastava

ABSTRACT

In this study, we attempted to synthesize five novel quinoline derivatives (4a-e) and evaluated them for their anti-convulsion bustle by maximal electric shock (Maximal Electrical Shock method). At starting stage, we synthesize 2chloroquinoline-3-carbaldehyde using VilsmeierHack reagent (DMFPOCI3) and acetanilide (1) at 05 °C. Compound (3) is allowed to react with different substituted amines to give a base intermediate. The corresponding schiff (4a-e). The final azeprisnone analogues (4a-e) were synthesized from the basic Schift intermediate (4a-e) by reaction with 1,4-dioxane and triethylamine. Final component of the edifice was confirmed on the basis of rudimentary analysis, FTIR, NMRH1 & NMR"C. All elemental analysis values are important. Pharmacological testing using peak electrophoresis (MES model) for anticonvulsant activity. Compounds (4a) and (4d) were initiate to be the greatest compelling compared to the typical drug Phenytoin.

Keywords: Vilsmeier-Hack reagent (DMF-POCI:) Quinoline, Anticonvulsant activity Maximal Electroshock(MESModel).