Abstract

PHARMACOGNOSTICAL AND PHARMACEUTICAL ANALYSIS OF NIRGUNDI GHRITA-AN AYURVEDIC HERBAL FORMULATION FOR CHRONIC BRONCHITIS

Manish Dubey*, Mandip Goyal, Harisha C. R. and Vinay J. Shukla

ABSTRACT

Background: Nirgundi is one of the most easily available and commonly used medicine in practice, which is indicated as one of the drugs for management of Kaphaja Kasa. Yet no study has been carried out over Nirgundi Ghrita in the management of Chronic bronchitis; Therefore, for better study the assurance of quality of herbal compounds pharmacognostical and pharmaceutical analysis should be done. Methods: Nirgundi Ghrita was subjected to microscopic evaluation for pharmacognostical, physiochemical analysis like Loss on drying, Acid insoluble extract, Specific gravity, Saponification, Iodine value and High-performance thin layer chromatography (HPTLC). Results: Pharmacognostical study showed the presence of certain identifying characters of the ingredients of Nirgundi Ghrita. In pharmaceutical study, preliminary physiochemical analysis showed Loss on drying 2.2% w/w, Specific gravity- 0.9259w/w, Acid value-1.7197w/w, Saponification - 47.333w/w, Iodine value-2.966w/w and HPTLC showed 17 spots in 254 nm and 26 spots in 366 nm. Conclusions: The Pharmacognostical and physico-chemical study of the formulated ghrita follows the standard parameters. This study can be helpful for further research regarding establishment of therapeutic efficacy of ghrita formulations.

Keywords: Nirgund Ghritai, Chronic Bronchitis, Pharmacognosy, Pharmaceutical analysis.