A RESEARCH ON NEW SYNTHETIC ROUTE OF ETHYL 4-(4-AMINOPHENYL)-6-METHYL-2-THIOXO-1, 2, 3, 4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE DERIVATIVES
*C. Suma, P. V. Thushara, Dr. T. K. Ajith Babu (M Pharm, PhD)
ABSTRACT
Dihydropyrimidone has become an important moiety for novel drug design. Dihydropyrimidone and derivatives are widely used in pharmaceutical industry due to the interesting pharmacological properties associated with this heterocyclic scaffold. A new series of novel Biginelli compounds, 3, 4 dihydropyrimidone derivatives, were synthesized from ethyl 4-(4-aminophenyl)-6-methyl-2-thioxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate, which was synthesized by Bignelli condensation method, Thiourea, ethyl acetoacetate and aldehyde undergoes one pot three component condensation reaction. Derivatives of ethyl 4-(4-aminophenyl)-6-methyl-2-thioxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate synthesized by Schiff base
reaction between Ethyl 4-(4-aminophenyl)-6-methyl-2-thioxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate and various aldehyde. Structures of all the synthesized compounds were characterized by spectroscopic methods.
Keywords: Dihydropyrimidone; Bignelli reaction.
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