FLAVONOIDS AND THEIR THERAPEUTIC POTENTIAL AS ANTI CANCER AGENTS: BIOSYNTHESIS, METABOLISM AND REGULATION.
Priya Katyal*, Neha Bhardwaj and Robinka Khajuria
ABSTRACT
Flavonoids are a class of plant secondary metabolites and are referred to as Vitamin P. They are a group of more than 4000 polyphenolic compounds that occur naturally in foods of plant origin. Flavonoids are widely distributed in plants, fulfilling many functions. They have been shown to possess a variety of biological activities at nontoxic concentrations in organisms. The role of dietary flavonoids in cancer prevention indicate that flavonoids have important effects on cancer chemoprevention and chemotherapy (Ren W, 2003). Many mechanisms of action have been identified, including carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis, differentiation and inhibition of angiogenesis.
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