Abstract

A STUDY ON ASSESSMENT OF ETIOLOGICAL FACTORS, TREATMENT PATTERN AND ITS IMPACT ON OUTCOME IN NEONATAL HYPERBILIRUBINEMIA PATIENT AT A TERTIARY CARE HOSPITAL

Dr. Kosigi Nagaraju*, Dr. Golla Kavitha, Dr. Gadwala Vinod, Dr. Kenchugundu Jagadeesh and Dr. Bhairam Balaji Kumar

ABSTRACT

To study most common etiological factors and to analyse impact of treatment patterns on serum bilirubin levels in the treatment of neonatal hyperbilirubinemia. Objectives: To assess the etiological factors, treatment pattern and outcome associated with each treatment pattern in patients with neonatal hyperbilirubinemia. Materials and Methods: In our study, we have included a total of 250 patients diagnosed with Neonatal Hyperbilirubinemia during the period of November to April 2020. Total serum bilirubin and fractional bilirubin levels were measured and patients are categorized into mild, moderate and severe and had the treatment with sunbath phototherapy and exchange transfusion. respectively. Data was analysed using descriptive statistics, paired and unpaired T test and one way ANOVA in MS –EXCEL software. Results: Among 250 neonates included in our study 64 are diagnosed with mild hyperbilirubinemia, 170 with moderate and 16 with severe and are treated with sunbath phototherapy and exchange transfusion. Mild hyperbilirubinemia the mean of bilirubin levels of sunbath serum bilirubin values were 2.13 ± 0.83mg/dl and Direct bilirubin mean 0.62 ± 0.30 mg/dl. Similarly, the mean Indirect bilirubin were 1.21 ± 0.43mg/dl.Moderate the mean of bilirubin levels of Phototherapy Serum bilirubin valves treatment values were3.87 ± 0.92 and Direct bilirubin mean 0.72 ± 0.46mg/dl. Similarly, the mean Indirect bilirubin were 2.78 ± 0.57mg/dl Severe. the mean of bilirubin levels of Exchange transfusion of Serum bilirubin valves treatment values were8.90 ± 0.76mg/dl and Direct bilirubin mean 2.46 ± 0.92 mg/dl. Similarly, the mean Indirect bilirubin were 4.09 ± 0.22 mg/dl. Conclusions: In our study among various etiological factors, we found out that physiological cause was the most common etiological factor followed by prematurity and pathological cause, Rh incompatibility is the only cause that is associated with mortality.

Keywords: All term newborns, Hyperbilirubinemia, Etiological factors, sunbath, phototherapy, exchange transfusion.