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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF PSEUDOMONAS AERUGINOSA ISOLATED FROM URINE SAMPLES OF HOSPITALIZED PATIENTS IN MEERUT, UTTAR PRADESH (INDIA)

*Devanand Prakash and R. S. Saxena

Department of Botany, Meerut College, Meerut, Uttar Pradesh, India.

ABSTRACT

Pseudomonas aeruginosa is a classic opportunistic pathogen because of its innate resistance to many antibiotics and disinfectants. It is also the most common Gram negative bacterium found in nosocomial infections causing various spectra of infections especially in neutropenic, immunocompromised, burns / tissue injury and cystic fibrosis patients all over the world. Recent advances in medicine such as the advent of more elaborate surgery and intensive care, the use of immunosuppressive drugs, the availability of invasive procedures and the increase in number of immunocompromised patients means there is a rise in patients with impaired immune defenses liable to nosocomial infections. The increasing incidence of infections caused by multidrug resistant organisms have caused attention to be focused on measures for fighting resistance, foremost of which is susceptibility surveillance. This study therefore determined the prevalence, antibiotic senstivity and resistant patterns of Pseudomonas aeruginosa strains from clinical specimens of hospilatized patients. In this study total twenty three Pseudomonas aeruginosa (17.42%) were isolated from 132 positive clinical samples of Urine. The results of disk sensitivity testing for the isolated P. aeruginosa showed that Tetracycline, Rifampicin, Carbenicillin, Amikacin and Sparfloxacin were the most resistant drugs (100%) followed by Piperacillin (95.65%), Ciprafloxacin (91.30%), Nalidixic acid and Norfloxacin in 86.96% cases each. All twenty three tested isolates were multidrug resistant. The most effective drugs were Aztreonam and Cefpodoxime which showed 95.65% antimicrobial sensitivity among all twenty three isolates of P. aeruginosa followed by Gentamycin (91.30%) and Co-trimaxazole (86.96%).

Keywords: Multi drug resistant, Pseudomonas aeruginosa, Antibiotic resistance, Nosocomial infection.


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