Abstract

EXPERIMENTAL EVALUATION OF STRIKUTAJA (WRIGHTIA TINCTORIA R. BR.) AND CHIRABILVA (HOLOPTELEA INTEGRIFOLIA PLANCHON) BARKS IN KITIBHA KUSTA (PSORIASIS)

Manasa R.*, Lalitha B. R. and Kavana K. S.

ABSTRACT

Kitibha is a type of kshudra Kusta. Symptoms like erythema, dryness, scaling of skin, discoloration etc., of psoriasis is similar to Kitibha Kusta /psoriasis. Psoriasis is long lasting, autoimmune skin disease characterized by erythematous, raised areas of abnormal skin with scales and discoloration.[1] It usually occurs in adults and rarely in children. Strikutaja (Wrightia tinctoria) stem bark and Chirabilva (Holoptelea. integrifolia) stem bark having Kustahara property, which are easily available, were selected for the evaluation of Anti-psoriatic activity. BALB-c Psoriasis mice model was taken for study of 8 groups with 6 animals in each group. PASI (Psoriasis Accessing Severity Index) score, and Histopathological changes in Skin were observed. Group II (Ps control) in comparison with Group I (normal), Group III-acitretin oral (<0.001), Group IV acitretin topical (<0.001), Group V SBE oral (<0.001), Group VI SBE topical (<0.001), Group VII CBE oral (<0.001), Group VIII CBE topical (<0.001) – Group IV (<0.001) has given Significant results as it is standard drug for psoriasis. Acitretin being standard drug both oral and topical has given significant results. Among SBE oral and CBE oral - SBE oral (0.001) had significant results. Among SBE topical and CBE topical –CBE topical (0.001) have significant results

Keywords: Kitibha kusta, Strikutaja (Wrightia tinctoria R.Br.), Chirabilva (Holpotelea integrifolia PLANCHON), BALB-C mice, Acitretin, Psoriaisis.