Abstract

ANTIDIABETIC AND ANTIOXIDANT POTENTIALS OF ALLIUM PARADOXUM IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Vinod Shinde, Shyam Kulkarni* and Manoj Naphade

ABSTRACT

Background: This study investigated the antidiabetic, anti-dyslipidemic and antioxidant activities of Allium paradoxum in streptozotocin-induced diabetic rats. Materials and Methods: Twenty-four (24) Wistar rats weighing (180-200g) were used and diabetes was induced with single intraperitoneal injection of streptozotocin (50mg/kgbw). The animals were randomly divided into four groups (6rats/group). Group I: control, Group II: diabetic control, Group III&IV: diabetic rats treated with 0.5ml of Allium paradoxum and 2mg/kgbw Glimepiride respectively for 7 weeks. Food and water intake were recorded daily, body weight and blood glucose levels were measured at weekly interval throughout the experiment. On the last day of the experiment, the animals were sacrificed and blood sample were collected for biochemical parameters estimation. Results: Administration of Allium paradoxum significantly (p<0.05) increased the body weight, feed intake with significant (p<0.05) reduction in water intake. The plasma blood glucose, triglycerides (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were significantly (p<0.05) lower in Allium paradoxum treated group, whereas the high-density lipoprotein cholesterol (HDL-C) level significantly (p<0.05) increased. Furthermore, Allium paradoxum administration significantly (p<0.05) reduced the malondialdehyde (MDA) level and significantly (p<0.05) increased total antioxidant capacity (TAC), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione perioxidase (GPx) and Catalase (CAT) levels. Liver enzymes and kidney function parameters were also decreased (p<0.05) significantly. Conclusion: The result of these findings demonstrated that Allium paradoxum possess hypoglycemic, anti-dyslipidemic and antioxidant properties. Allium paradoxum can be a source of alternative therapy for diabetes against the synthetic drugs.

Keywords: Allium paradoxum, Diabetes mellitus, Hyperglycemia, Hepatoprotective, Dyslipidemia, Antioxidant.