Abstract

GASTRO RETENTIVE DRUG DELIVERY SYSTEM: AN OVERVIEW

Prajapati Vishakha*, Rana Kavita, Chainesh Shah, Mitali Dalwadi and U. M. Upadhyay

ABSTRACT

In the pharmaceutical profession, oral controlled release and site specific drug delivery systems have piqued interest as a way to improve therapy with a number of key medications. To address physiological difficulties such as short stomach residence times and unexpected gastric emptying times, the concept of a revolutionary drug delivery mechanism evolved. Gastro retentive drug delivery system is one of these novel approaches to prolonged and continuous drug release to the upper part of the Gastrointestinal tract (GIT), which significantly extends the duration of drug release and improves bioavailability of drugs with narrow therapeutic windows, prolonging dosing intervals and increasing patient compliance. The current review briefly discusses the gasroretentive drug delivery system, including the physiology of the stomach, objectives, needs, criteria, factors affecting, advantages and disadvantages, approaches, marketed products, recent combinations, unsuitable drugs, evaluation parameters, and applications. This technique can be used to generate various medications that are unstable in alkaline pH, soluble in acidic pH, have a small absorption window, and have a specific site of action in the stomach.

Keywords: Gastro-retentive drug delivery system, Approaches of gastro-retentive system, Application, Evaluation parameters.