Abstract

FORMULATION DEVELOPMENT & EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF ZIDOVUDINE

Praveen Kumar*, Ms. Shradha Shende and Dr. Navjot Singh

ABSTRACT

The objective of the study was to design oral sustained release matrix tablets of Zidovudine using Hydroxy Propyl Methyl Cellulose (HPMC) K4M, Guar Gum and Ethyl Cellulose as the retardant polymers and study the effect of various formulation factors such as polymer proportion, polymer type and effect of filler type on the in vitro release of the drug. Matrix tablets were prepared by direct compression method and prepared tablets were evaluated for weight variation percentage friability, hardness thickness and in vitro dissolution studies. All the granules and formulations showed compliance with pharmacopieal standards. In vitro release studies revealed that the release rate decreased with increase polymer proportion and hydrophobic polymers retard the drug release more than hydrophilic polymers. The formulations ZID5 and ZID1 sustained release of drug for 10 hrs. With 96%, 98% release but ZID6 (15% of HPMC) using MCC as diluent drug releases 10 hours only. Because of swelling property of MCC increased the drug release profile to a small extent due to change in swelling at the tablet surface. The developed sustained release matrix tablets of Zidovudine with good initial release for first 2hrs (15-25%) and extended the release up to 10 hrs. can over come the disadvantages of conventional Zidovudine tablets.

Keywords: HIV, Zidovudine, Tablets, Polymers.