Abstract

PHOSPHOLIPID-BASED MIXED MICELLES- AN APPROACH FOR TOPICAL DELIVERY OF MANGIFERIN

Shalini Devi* and Shivali Singla

ABSTRACT

Mangiferin is hydrophobic drug that has been widely researched for its therapeutic activities that include anti-inflammatory, anti-viral, and analgesic, immunomodulatory, anti-oxidant, anti-diabetic and several more. But being a hydrophobic drug the challenge arises in delivering the drug appropriately at the target site. Solubilization of mangiferin is still a challenge in the pharmaceutical industry. This review outlines the use of phospholipid based mixed micelles as a means to address this issue. The phospholipid mixed micelles system is an important technique to improve the solubility of water-insoluble drugs and the drug can reach at the target site without drug precipitation upon aqueous dilution. The use of phospholipid mixed micelles not only improves the solubility of poorly soluble drug but also provide patient compliance and the drug can effectively show therapeutic activity at target site. Apart from listed advantages, the mixed micelles can be easily manufactured and can be freeze dried and sterilized by filtration. This article reviews the advantages and methods for formation of phospholipid based mixed micelles for poorly soluble drugs. An overview of reviews was conducted to locate published literature between 2000 and 2020.

Keywords: Mangiferin, hydrophobic drugs, mixed micelles, topical drug delivery, phospholipids, phosphatidylcholine (PC).