Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

FORMULATION AND EVALUATION OF EXTENDED RELEASE MATRIX TABLETS OF PROPRANOLOL HYDROCHLORIDE

Bura Jayasree, Lingala Srikanth and Sridhar Babu Gummadi*

ABSTRACT

Hypertension is the most life-threatening disease amongst all lifestyle diseases. So, there is always a need for such a dosage that can release the drug for a long period from a single dose which will reduce the dose burden for the patient. The propranolol HCl is a non-selective beta-adrenergic blocking agent extensively used in various cardiovascular diseases. In the present study matrix tablets of anti-hypertensive drug, propranolol HCl were prepared and evaluated. The HPMC, sodium alginate and xanthan gum was used as a rate retarding polymer. The present study results point out that the rate of propranolol HCL release from xanthan gum matrices is mainly controlled by the drug:xanthan gum ratio. When the concentration of xanthan gum was enhanced, the release of the drug from the matrix tablet was retarded.
The drug-polymer interaction studies were carried out by FTIR studies where it showed that there was no significant interaction. The in-vitro drug release was carried out for optimized formulation (F10) showed about 99.92 % drug release at 24 h. It was concluded that the matrix tablet of propranolol HCl by using xanthan gum can be prepared to get the desired release of the drug up to 24 h.

Keywords: Propranolol HCl, HPMC, sodium alginate and xanthan gum.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More