Abstract

HEPATOPROTECTIVE ACTIVITY OF FRESH FRUIT JUICE OF SYZYGIUM JAMBOS AGAINST ALCOHOL INDUCED HEPATOTOXICITY IN EXPERIMENTAL RATS

Harsha P. V.*, Kavyanjali K. V. and Ashoka Shenoy M.

ABSTRACT

The aim of present study was to investigate the Hepatoprotective activity of fresh fruit juice of Syzygium jambos in experimental rats against ethanol induced hepatotoxicity in rats. The efficacy of any hepatoprotective drug is essentially dependent on its capability of either reducing the harmful effects or in maintaining the normal hepatic physiological mechanism. Two doses 1ml/kg and 2ml/kg body weight p.o of the fruit juice were subjected for the evaluation of Hepatoprotective potential against ethanol (2ml/100g) induced liver injury. Silymarin (25mg/kg) was used as a standard drug. The parameters like SGPT, SGOT, ALP, Total Bilirubin and endogenous enzymes were estimated to assess the liver functions. Orally administered doses of 1 ml/kg and 2 ml/kg of fresh fruit juice of
Syzygium jambos produced significant decrease in AST, ALP, ALT levels and bilirubin. Syzygium jambos belongs to the family Myrtaceae. It was noticed that phytoconstituents such as phenolic compounds, flavanoids, vitamin C and triterpenes are involved in the hepatoprotective activity. The fruit exhibit antioxidant, antiviral, antiinflammatory and antimicrobial activity. In the liver sections of the rats treated with fresh fruit juice of Syzygium jambos and intoxicated with Alcohol and Paracetamol the normal cellular shape was retained as compared to silymarin, thereby confirming the protective effect of the fresh fruit juice of Syzygium jambos. The hepatoprotective activity of Syzygium jambos could be due to the presence of bioflavonoids which have hepatoprotective properties. The result of this investigation indicated that the fresh fruit juice of Syzygium jambos possess hepatoprotective activity against alcohol induced liver damage in rats.

Keywords: Hepatoprotective activity, Alcohol Induced Hepatotoxic activity, Syzygium jambos, Silymarin.