Abstract

FORMULATION AND EVALUATION OF RECONSTITUTABLE ORAL SUSPENSION OF CARBAMAZEPINE ORAL DOSAGE FORM

Pooja S. Gadekar*, Mukesh T. Mohite and Dr. Vaibhav Vaidya

ABSTRACT

Abstract: The objective of the present study is to develop dry suspensions for reconstitution like Carbamazepine using powder blends techniques. No any other commercial product available in combined dosage form. Reconstitutable oral suspension show sufficient chemical stability of the drug during shelf life, avoids the physical stability problems. These are the type of dry mixture that requires the addition of water at the time of dispensing. The prepared suspensions were examined for flow properties, rheological and sedimentation behavior. The reconstitution oral suspensions of carbamazepine were resulted to be stable over its intended shelf life of 15 days after reconstitution. Formulation with Xanthum gum (1.5% and 0.75%) showed excellent sedimentation volume and degree of flocculation nearing 1. This is because of the presence of anti caking agents or the granule disintegrant presentin the formulation. Also formulation with acasia showed good redispersibility.

Keywords: Carbamazepine, Xanthum gum, Flow properties.