Abstract

COMPARING THE INFLAMMATORY BIOMARKERS OF COVID-19 PATIENTS ASSOCIATED WITH AND WITHOUT COMORBIDITY - A RETROSPECTIVE STUDY IN TERTIARY CARE HOSPITAL

A. Jagadeesan, M. Sarukhan* and M. Karthika

ABSTRACT

Introduction: In December 2019, officials in Wuhan, China, reported the first case of human COVID-19, the disease caused by the new coronavirus, and was subsequently named SARS-CoV-2. Inflammatory markers such as procalcitonin (PCT), serum ferritin, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), D – dimer test is associated with the development of severe COVID-19. Objective: The objective of our study is to compare the inflammatory biomarkers of covid-19 patients associated with comorbidity and without comorbidity. Materials and Methods: All data were collected from the medical records by maintaining proper sampling techniques. In this study, about 100 records of COVID-19 patients with moderate to severe disease were retrospectively reviewed. Result: The mean CRP level of G-A was 29.42 mg/L and G-B was 22.82 mg/L. The mean CRP difference between two groups were 6.6 mg/L. The mean Ferritin level of G-A was 397.14 ng/ml and G-B was 280.97 ng/ml. The mean ferritin difference between two groups were 116.17 ng/ml. The mean D-dimer level of G-A was 833.21 ng/ml and G-B was 102.94 ng/ml. The mean D-Dimer difference between two groups were 730.27 ng/ml. This most significant difference compares to other inflammatory markers. The mean LDH level of G-A was 290.78 U/L and G-B was 246.98 U/L. The difference between two groups were 43.8 U/L. Conclusion: In our study inflammatory markers were spikely increased in comorbid patients (G-A) compared to the patients without comorbidity (G-B) due to the pathogenesis of COVID along with associated chronic conditions which speeds up the inflammatory reaction.

Keywords: COVID-19, Comorbidity, C – Reactive Protein, D – Dimer, Ferritin, Lactate dehydrogenase.