Abstract

A COMPARATIVE STUDY BETWEEN FUROSEMIDE AND TORSEMIDE ON FLUID OVERLOAD IN PATIENTS WITH CHRONIC KIDNEY DISEASE WITHOUT DIALYSIS IN A TERTIARY CARE HOSPITAL

Delsa P. Andrews*, Binny Babu, Greeshma Josephine Raj, Athulya Raj S., Subash B. Pillai and Santhosh M. Mathews

ABSTRACT

Loop diuretics are the commonly used drugs in the CKD patients to relieve fluid accumulation in body. Both furosemide and torsemide are used in chronic kidney disease patients as a treatment for fluid overload. In this study the effect of furosemide and torsemide on fluid overload in non-dialysis chronic kidney disease patients were compared. A total of 60 non-dialysis stage 3 or 4 CKD patients were included in this single centred hospital based prospective cohort study. 30 patients in the furosemide group were compared with 30 patients in the torsemide group for effect on diuresis and serum electrolytes level. The result showed that both drugs produced a 50-51% of diuresis. The effect of furosemide was decreasing and torsemide was increasing. Torsemide produced less decrease in serum sodium and serum potassium levels on 5th day of therapy. The study concluded that furosemide is the preferred drug for sudden action and for acute therapy while torsemide is the preferred one for sustained action and for prolonged therapy.

Keywords: Keywords: Furosemide, Torsemide, CKD, Fluid overload, Non-dialysis.