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  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

SAFETY AND EFFICACY OF MIRABEGRON AND SOLIFENACIN COMBINATION VS MIRABEGRON MONOTHEARPY IN OVERACTIVE BLADDER PATIENTS - A PROSPECTIVE OBSERVATIONAL STUDY

Tejomurthula Himasree*, Ganjimala Sukanya, Padamati Lakshmi Prasanna, Kantimohanthu Madhavi

ABSTRACT

Aim: The aim of the study is to compare the safety and efficacy of SOLIFENACIN and MIRABEGRON combination Vs monotherapy of MIRABEGRON in overactive bladder patients. Materials and Methods: This prospective observational study involves 50 patients and those who met the criteria were enrolled for the study. Relevant data such as demographics details, risk factors, past medical history, drug name, dose, route, frequency, duration of therapy, total pills per day was collected from profile form of the patient and by patient interview. Statistical consideration: All the raw data was collected, entered in excel sheet 2007 in windows 7 version, the statistical analysis was done in SPSS 16.0 software by an appropriate statistical methods Independent sample T test for knowing the significant p-value <0.005(confidence interval 95%). Results: We observed that out of 50 patients, 22(44%) patients were males and 28 (56%)patients were females. The peoples with overactive bladder mostly belong to the age group of 51-60 years. The mean of urinary urgency of these both groups was calculated statistically. The mean of urinary urgency with combination treatment (Mirabegron + Solifenacin) is2.04±0.93 and the mean of urinary urgency with monotherapy treatment (Mirabegron) is 1.28±0.73. This shows there is a significant difference between combination and monotherapy treatment. Conclusion: In our study we observed that combination treatment (MIRABEGRON + SOLIFENACIN) was safe and effective in treating patients with overactive bladder. The patient clinical and functional status was improved by his clinical manifestations ULTRASOUND SCANNING. The combination treatment (Mirabegron + Solifenacin) is as effective as monotherapy treatment and the improvement of medication adherence was due to the patient counselling.

Keywords: Oab, Ultrasound scanning


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