Abstract

FORMULATION AND EVALUATION OF GLIBENCLAMIDE LOADED PRONIOSOMAL GEL FOR TRANSDERMAL DRUG DELIVERY

Ranjeetha A. R.*, Vazir Ashfaq Ahmed, Priyanka Raj G., Swathi K., Rashmitha N. M., Monisha M. N., Vanendra Yadav

ABSTRACT

The aim of the present investigation, an attempt was made to formulate Glibenclamide loaded proniosomal gel in order to increase bioavailability and reduce side effects by achieving transdermal drug delivery. Proniosomal gel were prepared by co-accervation technique by varying the excipients .such as cholesterol, soyalecithin, span 60, span 40, tween 20. The prepared gel is characterized by particle size and zeta potential analysis, vesicle size distribution, surface morphology, determination of % drug content and % drug entrapment efficiency, in- vitro drug release. Drug and physical mixture were characterized by FTIR, which confirms that no interaction occur between drug and excipient. Zeta potential of optimized formulations were measured by zeta analyzer and found that-8.2mV(SF4), 6.3mV(S1F3), -5.7mV(TF3) and 3.1mV(T1F3) for the respective formulation, Which indicates they are sufficiently stable. The particle size also determined by Zeta particle analyzer for optimized formulation SF4 - 53.0nm, S1F3 - 51.5nm, TF3 - 52.4nm and T1F3 - 59.7nm.

Keywords: Glibenclamide, Proniosomes, co-accervation method, in vitro.