Abstract

FORMULATION OF PIPERINE HERBAL NANOPARTICLE AND IN VITRO EVALUATION

A. M. Akotkar*, S. M. Dabhade and A. P. Bodkhe

ABSTRACT

Novel drug delivery system is a unique method to delivery drug that formulate of herbal nanoparticles of piperine this novel formulation increase the activity and efficiency of piperine. The nanoparticles prepared from Long pepper fruit Extract, PVA solution 0.2% and Dichloromethane by using simple solvent evaporation method and also other preparation method of nanoparticles. This nanoparticles form improve various activity such as antimicrobial, Antifungal, Antioxidant, Hepatoprotective activity and Bioavailability of piperine. The observation found to be in vitro dissoluation parameter release pattern of piperine high as compared to simple Long pepper fruit Extract. Herbal nanoparticles are less side effect and less adverse effect. It is simple idea behind the novel drug delivery sytem in natural mediciness. Modern phytopharmaceutical research can solve the scientific needs (such as determination of pharmacokinetics, mechanism of action, site of action, accurate dose required etc.) of herbal medicines to be incorporated in novel drug delivery system.

Keywords: Novel drug delivery system recent objective in herbal plants.