Abstract

EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF GAMMA ORYZANOL EXTRACTED FROM RICE BRAN OIL

Sushil Yadav* and Neeraj Sharma

ABSTRACT

In the present study, γ – oryzanol was extracted from rice bran oil and to evaluate anti-inflammatory activity. Of the 5 methods under investigation, the one that yielded the highest γ -oryzanol content was further improved. The parameters under study were temperature, time, volume, and the ratio of ethyl acetate: hexane: isopropanol. Additionally, the extracts showed a strong anti-inflammatory activity through inhibitory effect on nitric oxide (NO). These results indicate that gamma-oryzanol rich extracts from rice bran oil is acting as a lipophilic radical scavenger better than a hydrophilic radical scavenger. Moreover, these extracts exert a potent anti-inflammatory activity.

Keywords: ? – Oryzanol, Rice bran, Inflammatory activity, Carrageenan paw edema.