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  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

FORMULATION DESIGN AND EVALUATION OF MOUTH DISSOLVING TABLET OF MILOXICAM USING DIFFERENT SUPERDISINTEGRANTS

Ravi Rajput*, Krishna Babu Ojha, Hritik Verma and Yadav Rupali Vinod

ABSTRACT

In this work, Mouth dissolving miloxicam tablets have been created with a view to improving patient conformity. A combination of superstructures (i.e. ac-di-sol), polyplasdone XL-10, microcrystalline cellulose pH 102 and immediately compressible dextrose was used to improve the feeling of the mouth. Tablet batches were assessed for hardness, coldness, uniformity of drug content, weathering duration, water absorption ratio and in vitro dispersion time. In the formulation prepared by direct compression method using Ac-di-sol (croscopy, in-vitro dispersion time) two formulations have been tested for in-vitro drug release pattern (in a pH 7.4 phosphate buffer), short-term stability at 25 °C ± 2°C/60 percent HR, 30 °C ± 2 °C/65 percent HR, 40 + C ± 2 °C/ 75% RH, and drug except interaction (IR spectroscopy) between the two formulations. Short-term stability experiments on the formulation showed no major variation in drug content and time for in vitro dispersion.

Keywords: Miloxicam, Superdisintegrants, Dissolution profile.


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