Abstract

A REVIEW ON ANALYTICAL METHOD FOR DETERMINATION OF BILASTINE IN BULK PHARMACEUTICAL DOSAGE FORM

Komal Wabale*, Ravindra Laware and Ganesh Shinde

ABSTRACT

Bilastine is Associate in Nursing anti-histaminic agent used for the treatment of allergic disorders like perissodactyl mammal inflammation and urtication. A simple, new RP-HPLC technique was developed and valid for the determination of purity of Bilastine in bulk and pharmaceutical indefinite quantity type. the aim of this analysis work to formulate the Formulation likewise as technique of Validation is additionally on check the various check are on value the one-dimensionality, Range, Specificity, Robustness, Accuracy, Force Degradation study, answer stability study check are on shown within the completely different variation or validation of a bilastine drug. The methanol: oxygen acid buffer in proportion of (70:30) was used as mobile part. The HPLC system consisting of LC20AD Prominence Liquid natural action SPD 20-A Shimadzu Japan. The UV-VIS detector and C18 column with dimension on 250×4.6 millimetre was Used at wavelength 280 nm.

Keywords: Bilastine, RP- HPLC, Validation, Method development.