Abstract

NANOEMULSION: A NOVEL APPROACH FOR ENHANCED THERAPEUTIC PROFILE

Sumedha R. Dani*, Smita S. Aher and Rishikesh S. Bacchav

ABSTRACT

Drug administration is preferred mostly through oral, topical and parenteral route. Poor bioavailability by these routes are noticeable with the majority of new active pharmaceutical ingredients due to its dissolution rate limited absorption. Failure to accomplish proposed therapeutic effects of the poorly water soluble drugs by these route directed the development of a new drug delivery system which will accomplish therapeutic. Nanoemulsions are submicron sized emulsions which act as drug carriers for improving the delivery of therapeutic agents. In pharmaceutical observation, nanoemulsion is one of the chief dosage forms in delivering active ingredients to the objective area which has engrossed a great attention in recent years for its application in various fields. In the pharmaceutical field, nanoemulsions have been used as a drug delivery system through various routes such as oral, topical and parenteral. Nanoemulsions are clear, thermodynamically stable, isotropic liquid mixtures of oil, water, surfactant and co-surfactant. These are oil-in-water (o/w) type of emulsions with the average droplet size ranging from 5nm to 100 nm. The present review provide comprehensive information on the advantages, disadvantages, methods of preparation, characterization techniques, applications, recent advances in the field.

Keywords: Nanoemulsion, Drug delivery system, Flocculation, Surfactants, Pharmaceutical applications.