Abstract

DRY EYE SYNDROME: A COMPREHENSIVE REVIEW

Sadiya Farhat J. P.*, Yuvraj Regmi, Sharmistha Panda, Roshan Gyawali and Rashmi Mathews

ABSTRACT

Dry Eye Syndrome (DES) is a very common, multifactorial disease of the lacrimal functional unit that results in hyperosmolarity, tear film instability, chronic irritation, and inflammation of the ocular surface. The ubiquity of Dry Eye is high, with worldwide estimation ranging from 5-50% of the total adult population. The notable diversity in the medical background of patients with DES and their sensitivity to symptoms provides a clear understanding of DES complications. It has become evident over the past few years that DES is a disorder of tear film which occurs because of deficiency of tear or excessive evaporation of tear. The cumulative annual cost (i.e. treatment) to the US economy of Dry Eye can be higher than 55 billion dollars. Consequently, the development of new treatments for Dry Eye is important for both the ophthalmic industry and Dry Eye patients. The major goal of the present review is to collect the different types of novel approaches in the treatment of DES.

Keywords: Dry Eye disease, artificial tears, inflammation, marketed formulation, Treatments, NSAIDs, keratoconjunctivitis sicca, surfactant.