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  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

A REVIEW ON ENHANCING THE BIOAVAILABILTY OF GRISEOFULVIN BY SOLID DISPERSION LOADED GEL

Sonam Shukla*, Rajneesh Kumar Gupta, Swarnakshi Upadhyay and Prateek Kumar

ABSTRACT

Out of many, one of the most promising strategies to improve the oral bioavailability of grisofelvin drugs is to develop amorphous solid dispersions. Reduction in drug particle size improves drug wettability and oral bioavailability significantly. Poorly soluble drugs are benefited by formulation approaches that overcome the issue of poor solubility and dissolution rate limited bio availability. Hence, to improve the solubility and dissolution of grisofelvin drugs, several formulation approaches can be considered, among which formulating the active pharmaceutical ingredient (API) in an amorphous form is recently gaining prominence. Formulating amorphous solid dispersions of grisofelvin drugs with water-soluble carriers has reduced the incidence of these problems and enhanced the rate of dissolution. This review mainly focuses on advantages, classification of solid dispersion, methods of preparation, and characterization of the amorphous solid dispersion.

Keywords: Griseuofelvin, Solid dispersion loaded gel, Bioavialbilty, Povidone, Mannitol.


[Full Text Article]

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