Abstract

ANALYTICAL METHODOLOGIES FOR DETERMINATION OF CHLORTHALIDONE AND CILNIDIPINE IN BULK AND PHARMACEUTICAL DOSAGE FORMS: AN OVERVIEW

Shrutika Gajanan Jagtap*, Santosh Govindrao Jadhav, Ashwini Janardan Thorat, Ashwini Shrikrushna Taware and Pragati Janardan Sorate

ABSTRACT

Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment. Chlorthalidone prevents reabsorption of sodium and chloride through inhibition of the Na+/Cl- symporter in the cortical diluting segment of the ascending limb of the loop of Henle. Cilnidipine is a Novel 4th generation calcium channel blocker. It is a calcium antagonist accompanied with L-type and N-type calcium channel blocking functions. The most commonly adopted methods for determination both drugs are UV-Visible Spectroscopy, HPLC (High Performance Liquid Chromatography), HPTLC (High Performance Thin Layer Chromatography). This article provides critical review on the methodologies available for qualitative and quantitative determination of chlorthalidone and cilnidipine in bulk and pharmaceutical dosage forms.

Keywords: Antihypertensive, Diuretic, chlorthalidone, cilnidipine, HPTLC, RP-HPLC, UV- Spectroscopy.