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Abstract

A REVIEW ON EXPERIMENTAL PHARMACOLOGY AND ANTI-INFLAMMATORY ACTION OF INDOMETHACIN

Simran Ajani* and Mr. Amit R. Jaiswal

ABSTRACT

In this era where the pharmaceutical companies and products are hiking in its need and production it is inevitable to document the safety and toxicity along with the indications of the same. This is where the experimental study has a vital role to play. Experimental pharmacology is the science where the drug interaction with different receptors and target sites in living organism are explained. Experimental Pharmacology deals with the effects of various test substances studied on different animal species which is aimed at finding out safe therapeutic agent suitable for public health as well as mechanism and site of action of a test substance. It is the basic step in the discovery of new drugs or studying the pharmacological action of already developed one using both preclinical and clinical study designs in a stepwise phase of investigations. However, the investigations in the first phase of experimental pharmacology are usually concluded with assumption or hypothesis without any adequate validation of the scientific evidence. Experimental pharmacology is based on the null technique since the biochemical reactions that transform receptor activation to cellular response are largely unknown.

Keywords: .


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