Abstract

COMPREHENSIVE REVIEW ON GASTRORETENTIVE DRUG DELIVERY SYSTEM: AN APPROACH TO ENHANCE GASTRIC RETENTION TIME AND ITS FUTURE POTENTIAL

Dipankar Kurmi* and Shaffi Tangri

ABSTRACT

The main objective of this review is the prolongation of Gastric retention to improve Bioavailability. Floating drug delivery system is a method to deliver the drugs that are active locally with a narrow absorption window in the upper gastrointestinal tract, unstable in the lower intestinal environment and posses low solubility with higher pH. The review highlights the prolongation of the GRT, including floating drug delivery system (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. Based on the mechanism of buoyancy, two distinctly different technologies, i.e. effervescent and non-effervescent systems, have been include in the development of FDDS. The parameters of evaluation and implementation of floating medication delivery systems are also summarised in this paper.

Keywords: FDDS, HBS, GRT.