Abstract

TO STUDY THE DRUG UTILIZATION AND EVALUATION OF PROTON PUMP INHIBITORS IN A TERTIARY CARE HOSPITAL

S. M. Biradar*, Akshay Kulkarni, Kartik Nuchhi, Shivanand I. Ludabude, Kirankumar Awati, Anand P. Ambali, Vijaykumar Warad, E.N. Gaviraj and S. C. Marapur

ABSTRACT

Aim: Proton Pump Inhibitors are the most widely prescribed drugs worldwide because of their outstanding efficacy and safety. Inappropriate use of PPIs has been observed in numerous hos¬pitals worldwide. The objective of this study was to assess utilization pattern of PPIs and to evaluate for its rational use. Methods: Prospective observational study was conducted for the period of six months in tertiary care hospital meeting the inclusion and exclusion criteria. 137 inpatients were selected from various departments to whom PPIs were prescribed and assessed for appropriate use of PPIs. Results: The study includes total number of 137 patients in which males were 80, and females were 57. Most of the patients with PPI prescription were between the age group of <20 years (26.3%). RTI related disorder was most prominent diagnosis found (32.1%) among selected patients. Pantoprazole (56.2%) was prescribed majorly among other class of PPIs. IV route was mostly preferred (64.2%). Considering the concurrent drugs used with PPI's, Antibiotics were prescribed in the most cases (93.4%). Across the overall study, majorly Indicated prescriptions were – 118 (86.1%) Possibly Indicated – 13 (9.5%) Not Indicated 4 – (4.4%). Totally 51 drug interactions were observed. Conclusion: The study found use of PPIs in wide range of indications. Efforts should be made by physicians to keep the constant vision on prescriptions to prevent inappropriate prescribing of PPIs with reference to the guidelines (FDA) available regarding their indication of use which would increase quality of prescription.

Keywords: PPIs, Inappropriate Utilization, Tertiary Care Hospital.