Abstract

SYNTHETIC STUDY OF INDOLE AND IT’S DERIVATIVES; AS POTENT ANTINEOPLASTIC AGENTS

Soumya Gulab Katre*, Alpana Jagdish Asnani and Kumar Pratyush, Sapan Kamleshkumar Shah, Ashish Suhasrao Moghe and Sachin Sheshrao Padole

ABSTRACT

Cancer is a disease that entails a loss of genomic stability and seems to have a high global mortality rate. Since its revealed, several people have been searching for an effective treatment, evaluating numerous compounds for their anticancer properties. Whereas, indoles are natural compounds with antineoplastic activities due to their propensity to trigger cell death in a variety of cancer cell lines. An indole is an aromatic heterocyclic composite which has its heterobicyclic configuration as a six-membered ring fused to a five-membered pyrrole ring. ‘Indole’ is the name given to all indole derivatives which have an indole ring system. Indole derivatives possess various biological activities, i.e. antiviral, anti-inflammatory, anti-cancer, anti-HIV, antioxidant, antimicrobial, anti-tubercular, antidiabetic, anticholinesterase, antimalarial activities, etc., prompting researchers to explore variety of indole derivatives. This review addresses the synthesis of indole and its various derivatives, facilitated induction and recent studies with indoles as showing potential chemotherapeutic activity.

Keywords: Indoles, heterobicyclic configuration, indole derivatives, biological activities, anti-cancer agents.