Abstract

DEGINE AND DEVELOPMENT OF TAMSULOSIN HYDROCHLORIDE SUSTAINED RELEASE TABLETS BY USING NATURAL GUM

Dr. Sathya Surya Prasad Ch.*, Parveen, P. Santhosh, P. Sai Kumar and P. Sivakali Bhargavi

ABSTRACT

The present of this research work to develop Tamsulosin hydrochloride 200 mg sustained release tablets. This is a selective antagonist at alpha-1A and alpha-1B adreno receptors. In this work four formulations are selected for design Tamsulosin hydrochloride sustained release formulations by using direct compression method and then the formulations are prepared by using different concentrations natural gum and different ingredients are used as fillers to develop the formula. The granules and tablets are evaluated by FT-IR, DSC, and pre-compression, post-compression and In-vitro dissolution studies. Based on the dissolution studies F2 was selected as an optimized formula because of it gives best results in sustained by drug release manner and best fitted to order of kinetics.

Keywords: Tamsulosin hydrochloride, Guar gum, Micro crystalline cellulose (MCC), Sustained release tablets.