Abstract

COMPARATIVE EVALUATION OF HYPOGLYCAEMIC EFFECT OF AEGLE MARMELOS FRUITS WITH MARKETED PREPARATIONS IN ALLOXAN INDUCED DIABETIC RATS

*Deepika Gupta, P.P. John, Pankaj Kumar, Faisal Amin

Department of Pharmacy, Ram-Eesh Institute of Vocational and Technical Education, Greater Noida.

ABSTRACT

Aegle marmelos Corr. (Rutaceae), commonly known as Bael, is a tree of Indian origin, well known from pre- historic time. Utilization of bael fruit in day-to-day life has a great nutritional, environmental as well as commercial importance. All the parts of this tree including stem, bark, root, leaves, fruit and seeds at all stages of maturity has medicinal virtues and has been used in Ethno medicine to exploits its medicinal properties. The hypoglycaemic effect of the methanolic extract of fruits of Aegle marmelos (MFE), was examined in alloxan induced diabetic Wistar rats and its comparative study was evaluated with marketed polyherbal formulation (PHF) ‘Madhunashini Vati’ containing bael fruit as one of its ingredients and Himalayan capsule (HBC) ‘Bael’ containing pure methanolic fruit extract. The fruit extract (250 mg kg-1), PHF (500 mg kg -1) and HBC (250 mg kg -1) were administered orally twice a day for a week and were compared with standard glibenclamide. The results showed significant reduction in blood glucose level. The results also revealed that MFE exhibited only 37% effect in PHF, which had78% of activity when compared standard glibenclamide (85%) and HBC having 36% of antidiabetic effect further confirming hypoglycaemic effect of the drug.

Keywords: Alloxan induced diabetes, Hypoglycaemic effect, Fruit extract, Herbal formulations; Glibenclamide.