WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

DETERMINATION OF SAFETY AND EFFICACY OF HARPAGOSIDE WITH DICLOFENAC IN POST OPERATIVE PAIN MANAGEMENT: A PROSPECTIVE COMPARATIVE STUDY

Bhushanam Gayatri*, Kursam Sahaja, G. Sadasiva Rao, Dr. S. Uma Shankar, Thokala Lakshmi Mounika and Kotha Pavani

ABSTRACT

Background information: Due to the low rate of complete recovery from postoperative pain after surgeries shows significant impact on the health and quality of life of patients and their families by causing pain, loss of function and mobility, depression, distress and anxiety, financial burden and prolonged hospital stays. Evidence suggests that postoperative pain impose significant and underappreciated burden to the individual, the healthcare system and the society as a whole. Harpagoside dose is 5mg which is available in capsule form. In this study, oral dosage form of harpagoside was used to determine its effect in the postoperative pain management of acute and chronic pains after surgeries. Materials and methods: It is an comparative study which involves 50 patients suffering from postoperative pain and were divided into 2 cohorts (test harpagoside and control-diclofenac). Visual analogue scale was used for the comparison of pain management in test and control groups in postoperative pain management. Results: Out of 50 subjects taken 25 subjects are treated with harpagoside and 25 subjects are treated with diclofenac. Of the 50 subjects taken 25 subjects are males and 25 subjects are females. Of 25 Subjects treated with harpagoside 10 subjects were discharged on day 3 which is early, 14 subjects are discharged on day4 and 1 subjects was discharged on day 5 without any complains of pain. Of 25 subjects treated with diclofenac 1 subject was discharged day 4, 12 subjects were discharged on day 5, 3 subjects are discharged on day 6 and 5 subjects are discharged on day 7 which is delayed and still with complaint of pain. statistical analysis was done in SPSS 16.0 software by an appropriate statistical methods independent T test for knowing the significant p-value <0.005 (confidence interval 95%). The mean pain score of harpagoside is 0.80 and mean pain score of diclofenac is 1.84. The difference between these two means shows a significance difference between these two drugs. When coefficient of variation was calculated between harpagoside and diclofenac, the cv of harpagoside is less than the cv of diclofenac. So, harpagoside is efficient than diclofenac. Conclusion: In this study harpagoside showed a good pharmacological effect when compared to diclofenac. Treating with harpagoside decreased postoperative pain in low doses and decreased hospital stay when compared to diclofenac. Harpagoside shows a significant beneficial effects other than pain management like wound healing with absence of any side effects.

Keywords: Postoperative pain management, Diclofenac, Harpagoside, Visual analogue scale.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More