Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF MODIFIED RELEASE FLOATING TABLETS OF MOSAPRIDE CITRATE

Mr. Sabale Ganesh Ramdas*, Ms. Chavan Gitanjali C., Mr. Jaiswal Naresh R. and Mr. Zambare K. K.

ABSTRACT

Gastro retentive offers several benefits such as rapid absorption, falling peak plasma fluctuation and ease of administration and termination of therapy. Hence, in the present work focused on controlling the release of drug for prolong period of time. In the evaluation of powder mixed blend of drug and excipients, bulk and tapped density was characterized. Results of the computed compressibility index and Hauser’s ratio show that the different formulations have sufficient compressibility and flow properties. Compatibility of the excipients used in the formulation with Mosapride citrate was done by mixing them in determine ratio. The samples were evaluated by FTIR. Results of the compatibility study revealed that the drug was compatible with the all excipients used in the formulation. Floating tablet was formulated using HPMC K4M, Carbopol 934, Sodium Bicarbonate and Citric acid anhydrous which is prepared by direct compression technique. The prepared tablet was evaluated for physical parameter, assay, swelling index, buoyancy lag time and In Vitro drug release. In the evaluation of the tablet, content uniformity test was performed by assay method by using UV spectrophotometer. Result was 100% in final formulation, which was acceptable. The swelling index and buoyancy lag time was also in acceptable range. In Vitro drug dissolution studies were done and it was within the acceptable predetermined criteria. The formulation containing 15% HPMC, 5% Carbopol 934 and 9% Sodium bicarbonate with citric acid anhydrous were consider as a best formulation with respect to perfect size and shaped and In-Vitro drug release profile. Gastroretentive drug delivery system gives unique release pattern, which was seen in optimized formulation. A floating gastroretentive tablets was prepared for prolonging the release of the drug in gastrointestinal tract for the treatment of a Gastro esophageal reflux disease.

Keywords: Mosapride Citrate, HPMC, Gastroretentive drug delivery system, swelling index and compatibility.