Abstract

N-BENZYL-AMINO FUMARAMATES: A NOVEL CLASS OF ANTIBACTERIAL AND ANTIOXIDANTS

Amudhavalli K., Senthilraja M.*, M. Vijayabaskaran and R. Sambathkumar

ABSTRACT

A series of novel N-benzylamino fumaramates derivatives (F1-F6) were obtained by the condensation of benzylamine with maleic anhydride in presence of thionyl chloride gives N-benzylamino fumaramic acid which reacts with various aliphatic & aromatic alcohol derivatives yields corresponding fumaramates. The formation of the N-benzylamino fumaramates was confirmed by IR, NMR, Mass spectra and Elemental analysis. All the synthesized compounds were screened for antibacterial and antioxidant activities using ciprofloxacin and ascorbic acid as a reference standard which shows a moderate to high potency against reference standards.

Keywords: N-benzylamino fumaramates; Antibacterial; Antioxidants; DPPH; Ciprofloxacin.