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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.485

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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Abstract

DEVELOPMENT AND VALIDATION OF SIMULTANEOUS EQUATION METHOD AND Q-ABSORBANCE RATIO METHOD FOR RIZATRIPTAN BENZOATE AND MELOXICAM IN BULK AND SYNTHETIC MIXTURE

Dr. Rajashree Mashru, Yashashree Mane

ABSTRACT

Two simple, precise, accurate and cost effective UV-Spectrophotometric methods were developed and validate for estimation of Rizatriptan Benzoate (RIZA) and Meloxicam (MELO) in bulk and their synthetic mixture. For simultaneous equation method, the estimation of Rizatriptan benzoate and Meloxicam was carried out at 227nm and 363nm for meloxicam. For Q absorption method, estimation of RIZA at 227 nm and MELO at 236.68nm (isobestic point of both the drug). Calibration curve of RIZA and MELO were found to be linear in concentration ranges of 3-11μg/ml and 6-22μg/ml, respectively, with their correlation coefficient value (R2) was more than0.996. In precision study, The % RSD value was found to (RSD

Keywords: Rizatriptan benzoate, Meloxicam, Simultaneous Equation Method, Q absorbance Ratio Method, ANOVA, t-Test.

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