Abstract

DEVELOPMENT AND EVALUATION OF LIPOSOME FORMULATION OF LULICONAZOLE

Pooja Dhote, Naveen Gupta*, Amit Rawat, Neeraj Sharma, Dharmendra Rajput Ankita Shukla

ABSTRACT

The main objective of this work was designed to prepare and evaluate the Luliconazole Liposomes. This formulation will target the site of action with effect of various stabilizers on drug entrapment efficiency, and to reduce the side effects by formulating non-pegylated Liposomes. The Liposomes were prepared by dried thin film hydration technique using rotary evaporator with drug, carrier, ammonium sulphate and stabilizers. The parameters like temperature, vacuum and RPM were maintained accordingly. The prepared Liposomes of LF-1, LF-2, LF-3, LF-4, LF-5 and LF-6 formulations were evaluated for physical and chemical characteristics like average vesicle size, shape and zeta potential. The prepared Liposomes of F1 to F6 were evaluated for % free drug and Assay, The % free drug was optimum in F6 (Negative) formulation when compared to other formulations of F1, F2, F3, F4 and F5. The Assay was optimum in F2 (Neutral) formulation when compared to other formulations of F1, F3, F4, F5 and F6. This developed liposomal drug delivery system was also evaluated for dissolution study by pH 7.4 phosphate buffer using membrane diffusion method. The release of drug from F6 (Negative) formulation was found to be sustained to certain extent when compared to F1, F2, F3, F4 and F5 formulations.

Keywords: Liposome; Formulation; Luliconazole; Particle size.