Abstract

A REVIEW: GASTRORETENTIVE DRUG DELIVERY SYSTEM

Rushikesh B. Katkar*, Amar S. Kulkarni, Chandrashekhar V. Babar, Pooja P. Patel

ABSTRACT

The aim of this review is to investigate, compile and present the recent as well as past literatures in more concise way with special focus on various gastro retentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. Gastro-retentive drug delivery system (GRDDS) has gained immense popularity in recent years in the field of oral drug delivery. It is widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. In order to understand various physiological difficulties to achieve gastric retention, we have summarized factors influencing and various strategies for gastric retention.

Keywords: GRDDS, Oral drug delivery, Bioavailability, Gastric retention, Gastric emptying time.