Abstract

A COMPREHENSIVE REVIEW ON ORAL IN-SITU GEL AS FLOATING DRUG DELIVERY SYSTEM

Rohinatha*, Vinayak K. and Dr. Shabaraya A. R.

ABSTRACT

The oral delivery of drugs having narrow absorption window in the gastro-intestinal tract is limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the time of absorption. New drug delivery systems have been developed to provide controlled drug delivery. Floating systems, mucoadhesive systems, high density systems, and expandable systems have all been developed to prolong gastric residence time. Because of the rapid transit time from the stomach to the duodenum, liquid orals are more prone to low bioavailability than other oral dosage forms. The transit time of the dosage form can be reduced to achieve sustained/controlled delivery. An approach using a liquid in-situ gelling system can help with this. These in-situ formulations are drug delivery systems that are in a sol state before being administered to the body, but then gel in the body. Temperature modulation, pH change, presence of ions, and ultraviolet irradiation all contribute to the formation of gel, from which drug releases in a sustained and controlled manner. Gellan gum, alginic acid, xyloglucan, pectin, chitosan, poly-caprolactone, poly-lactic acid and polylactic-co-glycolide are some of the polymers that can be used to make in-situ gels. This article provides a comprehensive overview of the introduction, methods for achieving in-situ gelling, polymers used, evaluation parameters, and benefits of in-situ gelling.

Keywords: Floating systems, Gastroretentive, Hydrogels, Temperature Sensitive, Buoyancy, Oral in-situ gel, Sustained release.