Abstract

A REVIEW ON PRECLINICAL SCREENING OF ANALGESIC EFFECTS OF BIOACTIVE PLANT EXTRACTS

Shivangi Kukshal*, Sudhakar Kaushik and Bhawana Bhatt

ABSTRACT

Analgesics have been widely used since long time for pain management, with lot of advancements being made with greater pharmacokinetic as well as pharmacodynamic improvement. Pain is the most common experience one undergoes May it be ache in our body parts, injury or after surgery. This unpleasant experience is one the major public health concern. Though there are a lot of non-pharmacological ways to treat pain but yet a lot of researches are being carried out every year for pain management. Although the synthetic analgesics are very useful in pain management but they come with many side effects. Due to the increasing number of side effects, there is an increase switch to a better alternative that is, plant based analgesics which is not only cost efficient but is also with fewer or no side effects. Animal models have been most widely used in the preclinical screening of drugs and are essential part of drug discovery. Various animal models based on different principles are used that are essential for the evaluation of central, peripheral or visceral analgesics. The aim of this review article is to study recent researches in the field of phytochemical analgesics, study various receptors and new plants that have potential pharmacological activities.

Keywords: Analgesics, Preclinical Screening, Plant based analgesics.