Abstract

ANALYSIS OF GENETIC VARIANTS AND MUTATIONS OF THE NOVEL CORONAVIRUS SARS-CoV-2

Momina Anzum A., Yuvan Sasi V., Sekar M., Pranav P., Sureya Prakash V., *Dr. R. Mahenthiran

ABSTRACT

SARS-CoV-2 is a new type of coronavirus causing a pandemic severe acute respiratory syndrome (SARS-2). Coronaviruses are very diverting genetically and mutate so often periodically.There are about 12,343 SARS-CoV-2 genome sequences are identified in different geographic area by researchers.This leads to extremely high rates of infectivity and can result in acute respiratory syndrome or even mortality. Finally, the drugs for COVID-19 treatment is still limited, with several candidates still under clinical trial and no effective therapeutic yet reported. Although vaccines based on either DNA/mRNA or protein have been deployed, their efficacy against emerging variants requires ongoing study, with multivalent vaccines supplanting the first-generation vaccines due to their low efficacy against new strains. Here, we provide a systematic review of studies on the epidemiology, immunological pathogenesis, molecular mechanisms, and new genomic variants, as well as approaches for vaccine development for SARS-C oV-2.

Keywords: SARS-CoV-2, Genomic strain, Mutation,Vaccine.