Abstract

A REVIEW: IN-VIVO AND IN-VITRO TESTING MODELS FOR ANTIALLERGIC FORMULATIONS

Mayuri More*, Sonal Konde and Vrushali Tambe

ABSTRACT

The allergic diseases are increasing on this globe over the years. There are four types of allergies like, type-1 (anaphylactic reactions), type-2 (cytotoxic reaction), type 3 (immunocomplex reactions), and type-4 (cell-mediated reactions). Hypersensitivity is among the common form of allergy. In this review, we have discussed in-vivo and in-vitro models for testing allergy like BALB/c, CH3/HeJ, C57BL/Mice, BN Rat, Zebrafish, Guinea Pig, Dog, Monkey, Cat, Pig, Sheep, Mast Cell, Human basophile, and RBL-2H3 etc. Dog are mostly used for human allergy testing as it is more related and shows common allergies same as humans. Mast cell play significant job in allergic study and RBL-2H3 cells play chief role in feed allergy. These models help in the development of new drug or novel therapy. The objective of this study is to develop allergy model and to analyse allergies throughout species and focus on how these allergies are equivalent in people.

Keywords: In-vivo and In-vitro models, IgE, allergy screening, antiallergics.