Abstract

CUBOSOMES: AN INNOVATIVE VESICULAR DRUG DELIVERY SYSTEM

Swarnali Dutta and Biswajit Basu*

ABSTRACT

Nanotechnology has brought a revolution in the field of science in recent years, which has subsequently lead to the development of novel dosage forms such as niosomes, liposomes, proniosomes, and cubosomes. Cubosomes have curvernous (Honeycomb) structure and it is a novel biocompatible drug delivery system whose diameter size range from 10–500 nm. The appearance of cubosomes is like spherical dots. Each dot contains a pore containing an aqueous cubic phase in the lipid water system. Because of its unique features, it is having great significance in the field of cosmeceuticals. It is an attractive choice of vehicle for in vivo drug delivery due to its low cost, safety, efficacy, and versatility for controlled release application and functionalization. Cubosomes can be administrated in different ways such as oral, percutaneous, and parenteral routes. Cubosomes can be prepared by following a very simple method and they can encapsulate hydrophobic and hydrophilic substances. Cubosomes offer high consequence in nano-based drug preparations for melanoma (skin cancer) treatment, targeted drug delivery systems and include a wide range of applications in many areas, and are characterized by various parameters. Consequently, cubosomes are in progress forward of awareness in the pharmaceutical division. This review mainly focuses on different aspects such as development, characterization, merits, demerits, applications, and current scenario in the market and future trends.

Keywords: Vesicular system, Biocompatible, Cubosomes, Characterization, Applications.