Abstract

FORMULATION AND IN-VITRO EVALUATION OF COMPRESSION COATED TABLETS OF ACECLOFENAC FOR CONTROLLED RELEASE

*Aruna. Ragidi, Madhuri J, Anusha. P, Venkateswara Rao. T

Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur, Andhra Pradesh, India, 522101.

ABSTRACT

The present study was carried out to develop oral controlled release formulations of Aceclofenac compression coated tablets by direct compression technique ,employing HPMC,ethyl cellulose and methyl cellulose as release retardant materials. . Compression coated tablets were formulated by preparing a core tablet containing 200mg of solid dispersions of Aceclofenac with polyvinyl pyrrolidine(PVPk30) in the ratio of 1:1 and then compressedcoated with the polymeric material. The characterization of physical mixture of drug and excipients was performed by infrared spectroscopy. The prepared tablets were characterized, the influence of coating layer on the core were studied, release rate was described by zero order, first order, higuchi and peppas equations. In vitro release data revealed that by increasing the quantity of coating layer by compression coating decreased the values of K, indicated that the release of drug was retarted up to 12 hr exhibit non-Fickian diffusion anomalous transport mechanism.

Keywords: Aceclofenac Compression coating, HPMC; Hydroxy propyl methyl cellulose