Abstract

CHRONIC VENOUS INSUFFICIENCY AND ITS TREATMENT: A REVIEW

Jagroop Singh*, Komalpreet Kaur and Ramninder Kaur

ABSTRACT

Chronic venous insufficiency (CVI) of the lower extremities is a complicated disorder that affects the productivity and well-being of millions of people worldwide. In CVI, veins in legs carry blood, back to heart is blocked and the valves do not work like they should and some of the blood may go back down into legs, that causes blood to pool or collect in the veins called (deep vein thrombosis).Over time, CVI can cause pain, swelling, and skin changes in legs. It may also lead to open sores called ulcers on legs. The standard treatment of CVI is compression bandaging, stocking, antibiotics (for ulcers) along with Phlebotropic drugs (flavonoid family). They are naturally or synthetic substances. Eg. diosmine, esperidine, troxoerutine, oxoerutine, etc. Their mechanisms of action vary, but their main property is activation of venous and lymphatic return. The effects of phlebotropic drugs on physiological parameters such us venous tone, venous haemodynamics, capillary permeability and lymphatic drainage have been studied by many well-conducted randomized, double-blind clinical trials.

Keywords: Chronic venous insufficiency, Flavnoids, phlebotropic drugs.