Abstract

COMPUTER -AIDED DRUGS DESIGN: ANALOGUES BASED DRUGS DESIGN AND DRUG DISCOVERY

Manyata Yadav*, Manoj Yadav, Shashikant Maury, Piyush Yadav and Asgar Shameem

ABSTRACT

The benefits of utilizing marketed drugs as starting points to discover new therapeutic agents have been well documented within the IUPAC series of books that bear the title Analogue-based Drug Discovery (ABDD). Not as clearly demonstrated, however, is that ABDD also contributes to the elaboration of new basic principles and alternative drug design strategies that are useful to the field of medicinal chemistry in general. After reviewing the ABDD programs that have evolved around the area of microtubule-stabilizing chemo - therapeutic agents, the present article delineates the associated research activities that additionally contributed to general strategies that can be useful for pro-drug design, identifying pharmacophores, circumventing multidrug resistance (MDR), and achieving targeted drug distribution.

Keywords: Introduction, SAR and receptor binding Studies, Optical Isomers Produced as Analogues, Analogue Design as a Means of Discovering New Drugs, The Pros and Cons of Analogue Design, Application.